Bio-1s 10mg

About This Compound

Bio-1s is a synthetic peptide analog built on a native incretin-family peptide backbone, modified with two amino-acid substitutions and a fatty-acid chain linked through a spacer to a lysine residue. The fatty-acid modification increases the peptide's affinity for circulating albumin, the design feature researchers use to extend a peptide's residence time in circulation — the way a courier who hitches a ride on a slower, longer-traveling vehicle covers more ground before running out of fuel. Bio-1s is studied for its receptor-binding characteristics and structural engagement with its target cell-surface receptor.

Research Context

Lau et al. (J Med Chem, 2015) detailed the structure-affinity relationships between fatty-acid chain length, linker chemistry, and albumin-binding affinity used in the design of this class of long-acting peptide analogs, reporting in vitro receptor-binding affinity and plasma half-life data in preclinical models (PMID 26308095). Zhang et al. (Cell Reports, 2021) used cryo-electron microscopy to resolve the structural dynamics of this peptide bound to its receptor in complex with a G protein, comparing peptide-receptor engagement across related analogs (PMID 34260945). Malgave et al. (J Pept Sci, 2025) examined the influence of pH, temperature, and buffer composition on the compound's physicochemical stability using orthogonal stability-indicating HPLC methods (PMID 40635175).

Research Use Disclaimer

For Research Use Only. Not for human consumption.