OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
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RUO
10mg
pep-SEL-10mg-us
Selank 10mg
CAS 129954-34-3
Selank is a synthetic heptapeptide analog of tuftsin studied for its effects on regulatory-peptide enzymology and gene expression. Kost et al. (Bioorg Khim, 2001; PMID 11443939) reported concentration-dependent inhibition of enkephalin-degrading enzymes in human serum. Sold research-grade, for laboratory use only. For Research Use Only. Not for human consumption.
$49.49Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic analog of tuftsin, an endogenous tetrapeptide, extended and modified for enzymatic stability. Enzymology research has characterized Selank as a concentration-dependent inhibitor of enkephalin-degrading enzymes in human serum, more potent in this assay than reference peptidase inhibitors such as bacitracin and puromycin. The way a decoy key jammed in a lock keeps the true key from turning, Selank is studied for how it occupies and inhibits the enzymes that would otherwise break down endogenous regulatory peptides.
Research Context
Kost, Sokolov, Gabaeva, Grivennikov, Andreeva, Myasoedov, and Zozulya (Bioorganicheskaya Khimiya, 2001; PMID 11443939) demonstrated a concentration-dependent inhibitory effect of Selank on enkephalin-degrading enzymes isolated from human serum, reporting a half-maximal inhibitory concentration more potent than the reference peptidase inhibitors bacitracin and puromycin. Volkova, Shadrina, Kolomin, Andreeva, Limborska, Myasoedov, and Slominsky (Frontiers in Pharmacology, 2016; PMID 26924987) used real-time PCR to profile the expression of 84 neurotransmission-related genes in rat frontal cortex following Selank administration, documenting expression changes in a subset of genes associated with the GABAergic system within one to three hours. Kolomin, Morozova, Volkova, Shadrina, Andreeva, Slominsky, Limborska, and Myasoedov (Molecular Immunology, 2014; PMID 24291245) tracked the temporal dynamics of gene expression for a panel of signaling genes in mouse spleen tissue after Selank administration, reporting time-dependent expression changes across several markers.
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-SEL-10mg-us
- Strength
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
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