OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
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RUO
2mg
pep-PMG-2mg-us
PEG MGF 2mg
CAS 108174-43-2
PEG MGF is a PEGylated form of the Mechano Growth Factor E-domain peptide, an IGF-1 splice-variant fragment. The unmodified E-domain peptide has been studied in rodent and cell-culture models for cell-migration signaling — CXCR4-ERK1/2 in mesenchymal stem cells (Luo et al., Growth Factors 2015, PMID 26260632), FAK-ERK1/2 in tenocytes (Zhang et al., Sci Rep 2016, PMID 26742689) — and for axon-guidance markers in cortical neurons (Liu et al., J Tissue Eng Regen Med 2018, PMID 27863093). PEGylation extends circulating half-life relative to the unmodified peptide. Research-grade material. For Research Use Only. Not for human consumption.
$55.54Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
PEG MGF is a synthetic, PEGylated version of the C-terminal E-domain peptide of Mechano Growth Factor (MGF), a splice variant of insulin-like growth factor 1 (IGF-1). PEGylation, the conjugation of a polyethylene glycol chain to a peptide backbone, is a chemistry technique studied for extending a peptide's circulating half-life relative to its unmodified form. The research below concerns the unmodified MGF E-domain peptide sequence, the parent structure PEG MGF is derived from. The way a longer wick burns more slowly than a short one, PEGylation is a chemistry method studied for extending a peptide's presence in circulation.
Research Context
Luo et al. reported that the MGF E-domain peptide (MGF-25E) was associated with rat bone-marrow-derived mesenchymal stem cell migration through activation of the CXCR4-ERK1/2 signaling pathway, along with changes in cell stiffness and F-actin polymerization (Growth Factors, 2015, PMID 26260632). Zhang et al. documented that a synthetic MGF E-domain peptide (MGF-C25E) was associated with increased nuclear stiffness and chromatin condensation in rat tenocytes via FAK-ERK1/2 signaling, a mechanism linked to tenocyte migration in that model (Sci Rep, 2016, PMID 26742689). Liu et al. investigated the MGF E-domain peptide (MGF-Ct24E) in primary cultured rat cortical neurons and adult rat brain tissue, reporting associations with Netrin-1/DCC expression and axonal elongation (J Tissue Eng Regen Med, 2018, PMID 27863093).
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-PMG-2mg-us
- Strength
- 2mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
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