OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
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RUO
10mg
pep-PE2-10mg-us
PE 22-28 10mg
PE 22-28 is a synthetic seven-amino-acid analog of spadin, a peptide fragment of sortilin studied for selective binding to the TREK-1 potassium channel. Patch-clamp studies reported a TREK-1 IC50 of 0.12 nM for PE 22-28 versus 40-60 nM for spadin, alongside mouse behavioral assays showing altered immobility-time and feeding-latency measures (Djillani et al., Front Pharmacol 2017, PMID 28955242). Research-grade material. For Research Use Only. Not for human consumption.
$54.44Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
PE 22-28 is a synthetic, shortened analog of spadin, a peptide identified as a proteolytic fragment of the protein sortilin. Spadin and its shortened analogs have been studied for their affinity toward TREK-1 (TWIK-related potassium channel-1), a two-pore-domain potassium channel implicated in neuronal excitability. The way a lock accepts only a matching key, PE 22-28 is studied for a tighter, more selective binding affinity to the TREK-1 channel than its parent peptide, spadin.
Research Context
Djillani et al. designed PE 22-28 from spadin blood-degradation products and reported, using patch-clamp electrophysiology on hTREK-1/HEK cells, a TREK-1 channel IC50 of 0.12 nM for PE 22-28 compared to 40-60 nM for spadin; in mouse behavioral assays including the forced swim test and novelty-suppressed feeding test, PE 22-28 was associated with altered immobility-time and feeding-latency measures, along with markers of hippocampal neurogenesis and increased PSD-95 expression in cortical neurons (Front Pharmacol, 2017, PMID 28955242). Spadin, the parent peptide, has been studied for selective TREK-1 blockade without the pain-, seizure-, or cardiac-conduction changes associated with other TREK-1-targeting approaches in rodent models (Moha Ou Maati et al., Neuropharmacology, 2012, PMID 21807005).
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-PE2-10mg-us
- Strength
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
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