N-Acetyl Epitalon Amidate 5mg

About This Compound

N-Acetyl Epitalon Amidate is a modified analog of Epitalon (Ala-Glu-Asp-Gly), a synthetic tetrapeptide first characterized by Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. The N-acetyl and C-terminal amidate modifications are structural changes intended to alter peptide stability relative to the parent sequence. Research on the parent Epitalon peptide has focused on telomerase activity and gene transcription in cultured human cells.

Research Context

Khavinson et al., 2003 documented that Epithalon peptide addition to telomerase-negative human fetal fibroblast cultures induced expression of the telomerase catalytic subunit and telomere elongation (Bull Exp Biol Med, PMID 12937682). A follow-up study by Khavinson et al., 2004 found that Epithalon-treated human fetal fibroblasts underwent additional population doublings beyond the culture's typical replicative limit (Bull Exp Biol Med, PMID 15455129). Khavinson et al., 2003 also proposed, based on conformational analysis, that the Epithalon tetrapeptide binds identified nucleotide sequences in the promoter regions of specific genes, including telomerase (Bull Exp Biol Med, PMID 14666197).

Research Use Disclaimer

For Research Use Only. Not for human consumption.