IGF-DES 10mg

About This Compound

Des(1-3)IGF-1 is a naturally occurring truncated variant of IGF-1 missing the N-terminal tripeptide Gly-Pro-Glu. The absence of this fragment changes its interaction with IGF-binding proteins in ways researchers have characterized extensively in cell and animal models. The way a key removed from a lock changes which doors it opens, removing this tripeptide is thought to change which binding partners the molecule can engage in cellular signaling pathways.

Research Context

Ballard et al. characterized Des(1-3)IGF-1 as a naturally occurring truncated variant with markedly reduced binding to IGF-binding proteins compared to native IGF-1, a property linked to greater potency in cultured-cell proliferation assays (Ballard et al., Int J Biochem Cell Biol, 1996 — PMID 8930132). Tomas et al. compared Des(1-3)IGF-1 against native IGF-1 and related analogs in pig and marmoset research models, examining hypoglycaemic potency and plasma glucose response across the analog series (Tomas et al., J Endocrinol, 1997 — PMID 9415072). Walton et al. reviewed a series of pig studies characterizing how variants with weaker IGF-binding-protein affinity differ from native IGF-1 across growth and metabolic research endpoints (Walton et al., Prog Growth Factor Res, 1995 — PMID 8817682).

Research Use Disclaimer

For Research Use Only. Not for human consumption.