OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
Loading product…
RUO
10mg
pep-HUM-10mg-us
Humanin 10mg
Humanin is a 24-amino-acid mitochondrial-derived peptide first confirmed in vivo by Tajima et al. (Neurosci Lett 2002; PMID 12009529), who raised an antibody detecting native peptide production in mouse tissue and human brain samples. Investigated across cellular stress-response and signaling pathways in subsequent research. Sold research-grade, for laboratory use only. For Research Use Only. Not for human consumption.
$231.54Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
Humanin is a 24-amino-acid peptide first identified through a functional screen of Alzheimer's disease brain cDNA, encoded within a region of the mitochondrial genome overlapping the 16S ribosomal RNA sequence. The way a cell's mitochondria send distress signals to the rest of the cell, Humanin has been characterized in the literature as a secreted signaling peptide studied across cellular stress-response and metabolic-signaling research pathways.
Research Context
Tajima, Niikura, Hashimoto, Ito, Kita, Terashita, Yamazaki, Koto, Aiso, and Nishimoto (Neurosci Lett 2002; PMID 12009529) raised an antibody against Humanin and detected the native peptide in mouse testis and colon tissue as well as in human brain tissue samples, establishing that the peptide is produced in vivo rather than existing only as a theoretical open reading frame. Takeshita, Hashimoto, Nawa, Uchino, and Matsuoka (J Biol Chem 2013; PMID 23861391) investigated the intracellular signaling pathway downstream of Humanin receptor binding in neuronal cell culture, identifying SH3 domain-binding protein 5 as a transcriptional target that binds and inhibits c-Jun N-terminal kinase. Muzumdar, Huffman, Atzmon, Buettner, Cobb, Fishman, Budagov, Cui, Einstein, Poduval, Hwang, Barzilai, and Cohen (PLoS One 2009; PMID 19623253) examined central and peripheral infusion of Humanin and Humanin-derived analogs in rodent models, reporting activation of hypothalamic STAT-3 signaling and an age-associated decline in circulating Humanin levels in both rodents and humans.
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-HUM-10mg-us
- Strength
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
Related
