OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
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RUO
10mg
pep-FXD-10mg-us
FOXO4-DRI 10mg
FOXO4-DRI is a D-retro-inverso isoform of a FOXO4-derived peptide, designed for protease resistance relative to its parent L-peptide. Kong et al. (Commun Biol 2025; PMID 39994346) investigated FOXO4-DRI in keloid fibroblast and organ-culture models, examining its association with p53 nuclear exclusion and apoptosis in senescent fibroblast populations. Sold research-grade, for laboratory use only. For Research Use Only. Not for human consumption.
$169.94Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
FOXO4-DRI is a D-retro-inverso isoform of a FOXO4-derived peptide, an amino-acid-reversed, D-configured design intended to confer protease resistance relative to the parent L-peptide. Research models have examined the compound's disruption of the FOXO4-p53 interaction and the resulting nuclear exclusion of p53 in senescent cells. The way a mirror-image key can be cut to resist a standard lock-picking approach, D-retro-inverso peptides like FOXO4-DRI are studied for extended stability against enzymatic breakdown compared with their L-amino-acid counterparts.
Research Context
Kong, Li, Liu, and colleagues (Commun Biol 2025; PMID 39994346) investigated FOXO4-DRI in keloid fibroblast and organ-culture models, examining its association with p53-serine-15 nuclear exclusion and apoptosis in senescent fibroblast populations. Li, Zhang, Cheng, and colleagues (Exp Gerontol 2024; PMID 39025385) studied FOXO4-DRI in a model of Leydig cell senescence in aged mice, examining apoptosis induction in senescent cells and secretory phenotype markers in cocultured cell systems. Liu, Hou, Wang, Liu, and Cheng (Naunyn Schmiedebergs Arch Pharmacol 2023; PMID 37074394) examined FOXO4-DRI in a bleomycin-induced pulmonary fibrosis mouse model, studying its association with extracellular matrix protein content and p53 nuclear distribution in fibroblasts.
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-FXD-10mg-us
- Strength
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
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