OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
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RUO
2mg
pep-FX4-2mg-us
FOXO4 2mg
FOXO4 is a forkhead-family transcription factor studied for its structural interaction with p53 in senescent cell biology research. Baar et al. (Cell 2017; PMID 28340339) identified FOXO4 as a factor in senescent cell viability and designed a FOXO4-derived peptide to study its effect on senescent cell populations in mouse models. Sold research-grade, for laboratory use only. For Research Use Only. Not for human consumption.
$82.49Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
FOXO4 is a member of the forkhead box class O (FOXO) family of transcription factors. Structural biology research has examined how the FOXO4 forkhead DNA-binding domain engages the p53 transactivation domain, an interaction studied in the context of senescent cell viability. The way removing a single wedge can release a jammed mechanism, a peptide designed to perturb the FOXO4-p53 interaction is studied for its selective effect on senescent cell populations.
Research Context
Baar, Brandt, Putavet, and colleagues (Cell 2017; PMID 28340339) identified FOXO4 as a factor in senescent cell viability and designed a FOXO4-derived peptide to perturb the FOXO4-p53 interaction, studying its effects on cell-intrinsic apoptosis in senescent cell populations and in mouse models. Kohoutova, Srb, Obsilova, Veverka, and Obsil (Nat Commun 2025; PMID 40425537) used NMR and structural biology methods to characterize the heterogeneous binding modes between the FOXO4 forkhead domain and the p53 transactivation domain. Asadi, Moundounga, Chakroborty, Pokokiri, and Wang (Front Mol Biosci 2025; PMID 40260403) reviewed the FOXO family of transcription factors, including FOXO4, and their regulation by the PI3K-Akt pathway in cell survival and stress-response research.
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-FX4-2mg-us
- Strength
- 2mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
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