Epitalon 10mg

About This Compound

Epitalon (also known as Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), developed by researchers at the Saint Petersburg Institute of Bioregulation and Gerontology as a synthetic analog of a naturally occurring component of the pineal gland's polypeptide complex. Telomeres cap the ends of chromosomes much as a plastic aglet caps the end of a shoelace; Epitalon has been examined in laboratory studies for its documented interaction with telomerase, the enzyme responsible for maintaining those caps.

Research Context

Al-Dulaimi et al. (2025, Biogerontology) exposed human breast cell lines and normal epithelial and fibroblast cells to Epitalon and documented concentration-dependent telomere length extension through hTERT mRNA and telomerase enzyme upregulation, with ALT (Alternative Lengthening of Telomeres) activation specific to the cancer cell lines used in the study. Khavinson et al. (2020, Molecules) examined AEDG peptide's documented relationship to neurogenic differentiation gene expression in human gingival mesenchymal stem cells, proposing histone binding as one possible epigenetic mechanism. An earlier study by Khavinson et al. (2017, Bulletin of Experimental Biology and Medicine) identified the AEDG peptide sequence within the pineal gland's polypeptide complex using mass spectrometry and HPLC. Epitalon appears on FDA's Category 2 bulk drug substance safety list, reflecting the absence of identified human safety data for this compound.

Research Use Disclaimer

For Research Use Only. Not for human consumption.