OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
Loading product…
RUO
10mg
pep-DHX-10mg-us
Dihexa 10mg
CAS 1401708-83-5
Dihexa is a blood-brain-barrier-penetrant small-molecule derivative of angiotensin IV, characterized in the literature as engaging the hepatocyte growth factor/c-Met receptor system independently of full-length HGF protein. Sun et al. (Brain Sciences, 2021; PMID 34827486) examined Dihexa in an APP/PS1 mouse model, reporting PI3K/AKT pathway activation and synaptic marker changes in brain tissue. For Research Use Only. Not for human consumption.
$36.29Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic small-molecule compound derived from angiotensin IV, developed as an orally available, blood-brain-barrier-penetrant analog. It has been characterized in the literature as a ligand for hepatocyte growth factor (HGF), inducing phosphorylation of the c-Met receptor and downstream signaling associated with dendritic and synaptic structural changes in laboratory models. The way a spare key cut to fit an existing lock can still turn the mechanism, Dihexa is described in research as engaging the HGF/c-Met signaling system independently of full-length HGF protein.
Research Context
Wright and Harding (Journal of Alzheimer's Disease, 2015; PMID 25649658) reviewed the brain HGF/c-Met receptor system as a research target, describing Dihexa's oral bioavailability, blood-brain-barrier penetration, and induction of dendritic arborization and synaptogenesis in laboratory models. Sun et al. (Brain Sciences, 2021; PMID 34827486) examined Dihexa in an APP/PS1 transgenic mouse model, reporting PI3K/AKT signaling pathway activation alongside changes in neuronal cell counts, synaptophysin protein expression, and inflammatory cytokine levels in brain tissue. Wells et al. (Journal of Huntington's Disease, 2024; PMID 38489193) tested Dihexa (also documented as PNB-0408) in a 3-nitropropionic-acid rat model of Huntington's-disease-like motor and metabolic symptoms and reported that the compound did not attenuate the 3-NP-induced deficits — a null result the authors present as an argument for further work in alternate models rather than as evidence of efficacy in this one.
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-DHX-10mg-us
- Strength
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
Related
