Chonluten

A synthetic tripeptide (Thr-Glu-Trp) from the Khavinson short-peptide bioregulator family, developed at the Saint Petersburg Institute of Bioregulation and Gerontology.

About This Compound

Chonluten (Thr-Glu-Trp, T-EW) is a three-residue synthetic peptide originally derived from work on bronchial epithelial tissue extracts in the Khavinson research group. It belongs to the broader Khavinson short-peptide family — ultrashort synthetic peptides identified through fragment analysis of animal-tissue polypeptide preparations, each associated with a distinct source tissue. The way plasma-derived tripeptides such as GHK sit at the interface between metal-binding and receptor-signaling chemistry, the Khavinson tripeptides are studied as small tissue-specific regulators of gene expression in cultured cells. Sold as lyophilized powder, research-grade purity.

Research Context

Avolio et al. (2022) characterized Chonluten in the human monocytic THP-1 cell line, examining tyrosine phosphorylation patterns of mitogen-activated cytoplasmic kinases and cytokine release patterns following bacterial lipopolysaccharide (LPS) stimulation. The paper reports that Chonluten was among the Khavinson peptides that inhibited TNF and IL-6 release from LPS-stimulated cells in vitro. Khavinson et al. (2020, Molecules) reviewed the T-EW peptide alongside other short peptides in the immunomodulator series, and Khavinson et al. (2020, Stem Cell Reviews) discussed how Khavinson tripeptides interact with epigenetic regulators of cell differentiation, including the lung-lineage AEDL peptide and other tissue-specific fragments.

Research Use Disclaimer

For Research Use Only. Not for human consumption.