OVAGE
RUO
20mg
pep-OVA-20mg-us
Ovagen
$75.34Out of stock
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RUO
5mg
pep-MK6-5mg-us
MK-677 5mg
CAS 159752-10-0
MK-677 (ibutamoren) is an orally active small molecule studied as a growth hormone secretagogue receptor (GHS-R1a) agonist in animal models. Lee et al. (Yonsei Medical Journal, 2018; PMID 30450851) documented a transient rise in growth hormone concentration in rats, without a corresponding change in body growth after six weeks. For Research Use Only. Not for human consumption. (57 words)
$20.34Out of stock
1
For laboratory research use only · Not for human or veterinary use.
Description
About this peptide
About This Compound
MK-677 (ibutamoren) is a synthetic small molecule that binds the growth hormone secretagogue receptor (GHS-R1a), the same receptor activated by the endogenous peptide hormone ghrelin. It has been studied in animal models for its downstream activity along the hypothalamic-pituitary somatotropic axis and for GHS-R1a-linked signaling in kidney and brain tissue. The way a spare key opens a lock built for a different original key, MK-677 is designed to activate the ghrelin receptor through an orally available small molecule rather than the native peptide.
Research Context
Lee et al. (Yonsei Medical Journal, 2018; PMID 30450851) studied oral MK-677 in rats over a six-week period, observing a transient rise in peak growth hormone concentration alongside an increase in hypothalamic somatostatin expression, without a corresponding change in body growth or IGF-1 levels at the study's endpoint. Sales da Silva et al. (Molecular and Cellular Endocrinology, 2020; PMID 32814069) used MK-677 as a GHS-R1a agonist tool compound in Wistar and spontaneously hypertensive rats to examine receptor-linked renal function and hemodynamic parameters. Tian et al. (Journal of Alzheimer's Disease, 2019; PMID 31594237) examined MK-677 in a transgenic mouse model of amyloid-beta pathology, finding increased hippocampal neurogenesis markers without a corresponding change in amyloid deposition, synaptic loss, or microglial activation measures.
Research Use Disclaimer
For Research Use Only. Not for human consumption.
Specifications
At a glance
- SKU
- pep-MK6-5mg-us
- Strength
- 5mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- COA
- Per lot, on file
- Availability
- Out of stock
Shipping & Storage
Handling this material
Shipping
Orders ship within 24 hours. Delivered via USPS Priority or standard FedEx unless expedited shipping is selected at checkout. Tracking is emailed on dispatch and mirrored in your account.
In-transit handling
Lyophilized vials are shelf-stable and ship at ambient temperature. Storage in our warehouse is cooled; shipment does not require refrigeration.
Long-term storage
Lyophilized vials are shelf-stable at ambient temperature; refrigeration (2–8°C) extends shelf life. Refer to the batch-specific Certificate of Analysis for material-specific storage guidance. Once reconstituted, follow the storage instructions on the batch COA. Not for human or animal consumption.
Returns
Because these are research-grade biologics, we cannot accept returns on opened vials. Damaged-in-transit shipments are replaced at no cost within 7 days of delivery.
Frequently asked
Common questions
No. Every SKU is labeled and sold strictly for laboratory research use only. These are not drugs, dietary supplements, or veterinary products. Research Use Only policy
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